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Gene 500/504 Hox Genes

• There are five classes in this section. We will discuss papers from the primary literature concerning Hox gene function and regulation. Students are required to read the assigned material and should be prepared to discuss all aspects of the papers. We will focus on the research papers in class--the reviews and introductory sections are provided to provide context and background.
• Read comments from 2004 or from 2003 about the class.
• How to read original research papers
• Review: Veraksa, A., Del Campo, M. and McGinnis, W. (2000). Developmental patterning genes and their conserved functions: from model organisms to humans. Mol Genet Metab 69, 85-100.
• Review: Pearson et al (2005) Modulating Hox gene functions during animal body patterning. Nat Rev Genet. 6(12):893-904
• Introduction to Hox Genes

• Hox Genes in Vertebral Development, Monday March 27, 2006
  • Introduction to Somite Segmentation and Vertebral Development
  • Wellik DM, Capecchi MR (2003) Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science 301:363-7.
  • Carapuco et al., (2005) Hox genes specify vertebral types in the presomitic mesoderm. Genes Dev 19(18):2116-21.


• Hox Genes in Motor Neuron Specification, Tuesday March 28, 2006
  • Review: Landmesser (2001) The acquisition of motoneuron subtype identity and motor circuit formation. Int J Dev Neurosci. 19(2):175-82
  • Review: Song and Pfaff (2005) Hox genes: the instructors working at motor pools. Cell 123(3):363-5.
  • Dasen et al., (2005) A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity. Cell 123(3):477-91.
    • Dasen et al., Supplementary Material


• Hox Genes in Limb Development, Wednesday March 29, 2006
  • Introduction to Limb Development
  • Kmita et al (2005) Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature 435(7045):1113-6.


• Hox Genes in Beetle Development, Thursday March 30, 2006
  • Review: Deutsch (2005) Hox and wings. Bioessays 27(7):673-5
  • Tomoyasu et al., Ultrabithorax is required for membranous wing identity in the beetle Tribolium castaneum. Nature 433(7026):643-7


• Regulation of Hox Genes by MicroRNAs, Monday April 3, 2006
  • Mansfield et al., (2004) MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet 36(10):1079-83
  • Ronshaugen et al (2005) The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings. Genes Dev 19(24):2947-52.